Week RS2 • 2025-09-14 • vs SF (Home)
Season 2025
| Rank | Player | POS |
Att | Yds | Avg | TD | Long |
| 1 |
Christian McCaffrey |
RB |
13 |
55 |
4.2 |
0 |
10 |
| 2 |
Brian Robinson Jr. |
RB |
6 |
20 |
3.3 |
0 |
7 |
Week RS3 • 2025-09-21 • vs SEA (Away)
Season 2025
| Rank | Player | POS |
Att | Yds | Avg | TD | Long |
| 1 |
Kenneth Walker III |
RB |
16 |
38 |
2.4 |
2 |
10 |
Week RS4 • 2025-09-28 • vs BUF (Away)
Season 2025
| Rank | Player | POS |
Att | Yds | Avg | TD | Long |
| 1 |
James Cook |
RB |
22 |
117 |
5.3 |
1 |
15 |
| 2 |
Ray Davis |
RB |
1 |
3 |
3.0 |
0 |
3 |
Week RS5 • 2025-10-05 • vs NYG (Home)
Season 2025
| Rank | Player | POS |
Att | Yds | Avg | TD | Long |
| 1 |
Devin Singletary |
RB |
6 |
20 |
3.3 |
0 |
7 |
Week RS6 • 2025-10-12 • vs NE (Home)
Season 2025
| Rank | Player | POS |
Att | Yds | Avg | TD | Long |
| 1 |
TreVeyon Henderson |
RB |
9 |
27 |
3.0 |
0 |
7 |
| 2 |
Rhamondre Stevenson |
RB |
13 |
18 |
1.4 |
0 |
7 |
Week RS7 • 2025-10-19 • vs CHI (Away)
Season 2025
| Rank | Player | POS |
Att | Yds | Avg | TD | Long |
| 1 |
D'Andre Swift |
RB |
19 |
124 |
6.5 |
1 |
23 |
| 2 |
Kyle Monangai |
RB |
13 |
81 |
6.2 |
1 |
24 |
Week RS8 • 2025-10-26 • vs TB (Home)
Season 2025
| Rank | Player | POS |
Att | Yds | Avg | TD | Long |
| 1 |
Rachaad White |
RB |
13 |
35 |
2.7 |
0 |
9 |
| 2 |
Sean Tucker |
RB |
12 |
42 |
3.5 |
1 |
15 |
Week RS10 • 2025-11-09 • vs CAR (Away)
Season 2025
| Rank | Player | POS |
Att | Yds | Avg | TD | Long |
| 1 |
Rico Dowdle |
RB |
18 |
53 |
2.9 |
1 |
14 |
| 2 |
Chuba Hubbard |
RB |
3 |
14 |
4.7 |
0 |
6 |
Week RS12 • 2025-11-23 • vs ATL (Home)
Season 2025
| Rank | Player | POS |
Att | Yds | Avg | TD | Long |
| 1 |
Bijan Robinson |
RB |
14 |
70 |
5.0 |
0 |
32 |
| 2 |
Tyler Allgeier |
RB |
12 |
44 |
3.7 |
0 |
13 |
Week RS13 • 2025-11-30 • vs MIA (Away)
Season 2025
| Rank | Player | POS |
Att | Yds | Avg | TD | Long |
| 1 |
De'Von Achane |
RB |
22 |
134 |
6.1 |
1 |
29 |
| 2 |
Jaylen Wright |
RB |
3 |
16 |
5.3 |
0 |
8 |
Week RS14 • 2025-12-07 • vs TB (Away)
Season 2025
| Rank | Player | POS |
Att | Yds | Avg | TD | Long |
| 1 |
Bucky Irving |
RB |
15 |
55 |
3.7 |
0 |
32 |
| 2 |
Rachaad White |
RB |
11 |
53 |
4.8 |
0 |
11 |
Week RS15 • 2025-12-14 • vs CAR (Home)
Season 2025
| Rank | Player | POS |
Att | Yds | Avg | TD | Long |
| 1 |
Rico Dowdle |
RB |
16 |
49 |
3.1 |
1 |
8 |
| 2 |
Chuba Hubbard |
RB |
8 |
29 |
3.6 |
0 |
10 |
