Week RS1 • 2025-09-07 • vs CIN (Home)
Season 2025
| Rank | Player | POS |
Att | Yds | Avg | TD | Long |
| 1 |
Chase Brown |
RB |
21 |
43 |
2.0 |
1 |
8 |
Week RS2 • 2025-09-14 • vs BAL (Away)
Season 2025
| Rank | Player | POS |
Att | Yds | Avg | TD | Long |
| 1 |
Derrick Henry |
RB |
11 |
23 |
2.1 |
0 |
8 |
Week RS3 • 2025-09-21 • vs GB (Home)
Season 2025
| Rank | Player | POS |
Att | Yds | Avg | TD | Long |
| 1 |
Josh Jacobs |
RB |
16 |
30 |
1.9 |
0 |
7 |
| 2 |
Emanuel Wilson |
RB |
6 |
25 |
4.2 |
0 |
9 |
Week RS4 • 2025-09-28 • vs DET (Away)
Season 2025
| Rank | Player | POS |
Att | Yds | Avg | TD | Long |
| 1 |
Jahmyr Gibbs |
RB |
15 |
91 |
6.1 |
1 |
24 |
| 2 |
David Montgomery |
RB |
9 |
12 |
1.3 |
0 |
4 |
Week RS5 • 2025-10-05 • vs MIN (Home)
Season 2025
| Rank | Player | POS |
Att | Yds | Avg | TD | Long |
| 1 |
Jordan Mason |
RB |
13 |
52 |
4.0 |
1 |
14 |
| 2 |
Zavier Scott |
RB |
5 |
18 |
3.6 |
0 |
9 |
Week RS6 • 2025-10-12 • vs PIT (Away)
Season 2025
| Rank | Player | POS |
Att | Yds | Avg | TD | Long |
| 1 |
Jaylen Warren |
RB |
11 |
52 |
4.7 |
0 |
11 |
| 2 |
Kenneth Gainwell |
RB |
6 |
22 |
3.7 |
0 |
10 |
Week RS7 • 2025-10-19 • vs MIA (Home)
Season 2025
| Rank | Player | POS |
Att | Yds | Avg | TD | Long |
| 1 |
De'Von Achane |
RB |
13 |
82 |
6.3 |
0 |
46 |
| 2 |
Ollie Gordon II |
RB |
5 |
11 |
2.2 |
0 |
8 |
Week RS8 • 2025-10-26 • vs NE (Away)
Season 2025
| Rank | Player | POS |
Att | Yds | Avg | TD | Long |
| 1 |
TreVeyon Henderson |
RB |
10 |
75 |
7.5 |
0 |
27 |
| 2 |
Rhamondre Stevenson |
RB |
14 |
34 |
2.4 |
0 |
9 |
Week RS10 • 2025-11-09 • vs NYJ (Away)
Season 2025
| Rank | Player | POS |
Att | Yds | Avg | TD | Long |
| 1 |
Breece Hall |
RB |
21 |
83 |
4.0 |
0 |
30 |
| 2 |
Isaiah Davis |
RB |
3 |
10 |
3.3 |
0 |
10 |
Week RS11 • 2025-11-16 • vs BAL (Home)
Season 2025
| Rank | Player | POS |
Att | Yds | Avg | TD | Long |
| 1 |
Derrick Henry |
RB |
18 |
103 |
5.7 |
1 |
59 |
| 2 |
Keaton Mitchell |
RB |
6 |
31 |
5.2 |
0 |
10 |
Week RS12 • 2025-11-23 • vs LV (Away)
Season 2025
| Rank | Player | POS |
Att | Yds | Avg | TD | Long |
| 1 |
Ashton Jeanty |
RB |
17 |
50 |
2.9 |
0 |
12 |
| 2 |
Raheem Mostert |
RB |
1 |
2 |
2.0 |
0 |
2 |
Week RS13 • 2025-11-30 • vs SF (Home)
Season 2025
| Rank | Player | POS |
Att | Yds | Avg | TD | Long |
| 1 |
Christian McCaffrey |
RB |
20 |
53 |
2.7 |
1 |
7 |
| 2 |
Brian Robinson Jr. |
RB |
8 |
26 |
3.3 |
0 |
9 |
Week RS14 • 2025-12-07 • vs TEN (Home)
Season 2025
| Rank | Player | POS |
Att | Yds | Avg | TD | Long |
| 1 |
Tony Pollard |
RB |
25 |
161 |
6.4 |
2 |
65 |
| 2 |
Tyjae Spears |
RB |
8 |
19 |
2.4 |
0 |
8 |
Week RS15 • 2025-12-14 • vs CHI (Away)
Season 2025
| Rank | Player | POS |
Att | Yds | Avg | TD | Long |
| 1 |
D'Andre Swift |
RB |
18 |
98 |
5.4 |
2 |
17 |
| 2 |
Kyle Monangai |
RB |
11 |
33 |
3.0 |
0 |
9 |
