Week RS1 • 2025-09-07 • vs HOU (Home)
Season 2025
| Rank | Player | POS |
Att | Yds | Avg | TD | Long |
| 1 |
Woody Marks |
RB |
3 |
3 |
1.0 |
0 |
2 |
| 2 |
Nick Chubb |
RB |
13 |
60 |
4.6 |
0 |
13 |
Week RS2 • 2025-09-14 • vs TEN (Away)
Season 2025
| Rank | Player | POS |
Att | Yds | Avg | TD | Long |
| 1 |
Tony Pollard |
RB |
20 |
92 |
4.6 |
0 |
10 |
Week RS3 • 2025-09-21 • vs PHI (Away)
Season 2025
| Rank | Player | POS |
Att | Yds | Avg | TD | Long |
| 1 |
Saquon Barkley |
RB |
18 |
46 |
2.6 |
0 |
12 |
Week RS4 • 2025-09-28 • vs IND (Home)
Season 2025
| Rank | Player | POS |
Att | Yds | Avg | TD | Long |
| 1 |
Jonathan Taylor |
RB |
17 |
76 |
4.5 |
0 |
12 |
Week RS5 • 2025-10-02 • vs SF (Home)
Season 2025
| Rank | Player | POS |
Att | Yds | Avg | TD | Long |
| 1 |
Christian McCaffrey |
RB |
22 |
57 |
2.6 |
0 |
8 |
| 2 |
Brian Robinson Jr. |
RB |
5 |
12 |
2.4 |
0 |
5 |
Week RS6 • 2025-10-12 • vs BAL (Away)
Season 2025
| Rank | Player | POS |
Att | Yds | Avg | TD | Long |
| 1 |
Derrick Henry |
RB |
24 |
122 |
5.1 |
0 |
12 |
Week RS7 • 2025-10-19 • vs JAX (Away)
Season 2025
| Rank | Player | POS |
Att | Yds | Avg | TD | Long |
| 1 |
Travis Etienne Jr. |
RB |
8 |
44 |
5.5 |
0 |
13 |
| 2 |
Bhayshul Tuten |
RB |
5 |
22 |
4.4 |
0 |
8 |
Week RS10 • 2025-11-09 • vs SF (Away)
Season 2025
| Rank | Player | POS |
Att | Yds | Avg | TD | Long |
| 1 |
Christian McCaffrey |
RB |
12 |
30 |
2.5 |
0 |
5 |
| 2 |
Brian Robinson Jr. |
RB |
8 |
41 |
5.1 |
1 |
13 |
Week RS11 • 2025-11-16 • vs SEA (Home)
Season 2025
| Rank | Player | POS |
Att | Yds | Avg | TD | Long |
| 1 |
Kenneth Walker III |
RB |
16 |
67 |
4.2 |
1 |
25 |
| 2 |
Zach Charbonnet |
RB |
11 |
37 |
3.4 |
0 |
6 |
Week RS12 • 2025-11-23 • vs TB (Home)
Season 2025
| Rank | Player | POS |
Att | Yds | Avg | TD | Long |
| 1 |
Rachaad White |
RB |
7 |
38 |
5.4 |
0 |
16 |
| 2 |
Sean Tucker |
RB |
12 |
42 |
3.5 |
0 |
9 |
Week RS13 • 2025-11-30 • vs CAR (Away)
Season 2025
| Rank | Player | POS |
Att | Yds | Avg | TD | Long |
| 1 |
Rico Dowdle |
RB |
18 |
58 |
3.2 |
0 |
17 |
| 2 |
Chuba Hubbard |
RB |
17 |
83 |
4.9 |
0 |
10 |
Week RS14 • 2025-12-07 • vs ARI (Away)
Season 2025
| Rank | Player | POS |
Att | Yds | Avg | TD | Long |
| 1 |
Michael Carter |
RB |
3 |
13 |
4.3 |
0 |
9 |
Week RS15 • 2025-12-14 • vs DET (Home)
Season 2025
| Rank | Player | POS |
Att | Yds | Avg | TD | Long |
| 1 |
Jahmyr Gibbs |
RB |
13 |
38 |
2.9 |
0 |
6 |
| 2 |
David Montgomery |
RB |
7 |
32 |
4.6 |
1 |
10 |
