Week RS1 • 2025-09-07 • vs SF (Home)
Season 2025
| Rank | Player | POS |
Att | Yds | Avg | TD | Long |
| 1 |
Christian McCaffrey |
RB |
22 |
69 |
3.1 |
0 |
13 |
| 2 |
Brian Robinson Jr. |
RB |
9 |
33 |
3.7 |
0 |
9 |
Week RS2 • 2025-09-14 • vs PIT (Away)
Season 2025
| Rank | Player | POS |
Att | Yds | Avg | TD | Long |
| 1 |
Jaylen Warren |
RB |
14 |
48 |
3.4 |
0 |
9 |
| 2 |
Kenneth Gainwell |
RB |
5 |
20 |
4.0 |
0 |
13 |
Week RS3 • 2025-09-21 • vs NO (Home)
Season 2025
| Rank | Player | POS |
Att | Yds | Avg | TD | Long |
| 1 |
Alvin Kamara |
RB |
18 |
42 |
2.3 |
0 |
8 |
Week RS4 • 2025-09-25 • vs ARI (Away)
Season 2025
| Rank | Player | POS |
Att | Yds | Avg | TD | Long |
| 1 |
Michael Carter |
RB |
1 |
1 |
1.0 |
0 |
1 |
| 2 |
Emari Demercado |
RB |
2 |
8 |
4.0 |
0 |
8 |
Week RS5 • 2025-10-05 • vs TB (Home)
Season 2025
| Rank | Player | POS |
Att | Yds | Avg | TD | Long |
| 1 |
Rachaad White |
RB |
14 |
41 |
2.9 |
2 |
12 |
| 2 |
Sean Tucker |
RB |
3 |
3 |
1.0 |
0 |
3 |
Week RS6 • 2025-10-12 • vs JAX (Away)
Season 2025
| Rank | Player | POS |
Att | Yds | Avg | TD | Long |
| 1 |
Travis Etienne Jr. |
RB |
12 |
27 |
2.3 |
0 |
7 |
| 2 |
Bhayshul Tuten |
RB |
2 |
14 |
7.0 |
0 |
8 |
Week RS7 • 2025-10-20 • vs HOU (Home)
Season 2025
| Rank | Player | POS |
Att | Yds | Avg | TD | Long |
| 1 |
Woody Marks |
RB |
10 |
15 |
1.5 |
0 |
11 |
| 2 |
Nick Chubb |
RB |
5 |
16 |
3.2 |
0 |
5 |
Week RS10 • 2025-11-09 • vs ARI (Home)
Season 2025
| Rank | Player | POS |
Att | Yds | Avg | TD | Long |
| 1 |
Michael Carter |
RB |
3 |
4 |
1.3 |
0 |
6 |
| 2 |
Emari Demercado |
RB |
4 |
64 |
16.0 |
0 |
55 |
Week RS11 • 2025-11-16 • vs LAR (Away)
Season 2025
| Rank | Player | POS |
Att | Yds | Avg | TD | Long |
| 1 |
Kyren Williams |
RB |
12 |
91 |
7.6 |
1 |
34 |
| 2 |
Blake Corum |
RB |
8 |
10 |
1.3 |
0 |
6 |
Week RS12 • 2025-11-23 • vs TEN (Away)
Season 2025
| Rank | Player | POS |
Att | Yds | Avg | TD | Long |
| 1 |
Tony Pollard |
RB |
11 |
20 |
1.8 |
0 |
5 |
| 2 |
Tyjae Spears |
RB |
3 |
4 |
1.3 |
0 |
3 |
Week RS13 • 2025-11-30 • vs MIN (Home)
Season 2025
| Rank | Player | POS |
Att | Yds | Avg | TD | Long |
| 1 |
Aaron Jones Sr. |
RB |
6 |
3 |
0.5 |
0 |
4 |
| 2 |
Jordan Mason |
RB |
6 |
47 |
7.8 |
0 |
24 |
Week RS14 • 2025-12-07 • vs ATL (Away)
Season 2025
| Rank | Player | POS |
Att | Yds | Avg | TD | Long |
| 1 |
Bijan Robinson |
RB |
20 |
86 |
4.3 |
0 |
11 |
| 2 |
Tyler Allgeier |
RB |
11 |
34 |
3.1 |
0 |
9 |
Week RS15 • 2025-12-14 • vs IND (Home)
Season 2025
| Rank | Player | POS |
Att | Yds | Avg | TD | Long |
| 1 |
Jonathan Taylor |
RB |
25 |
87 |
3.5 |
0 |
11 |
| 2 |
Ameer Abdullah |
RB |
4 |
15 |
3.8 |
0 |
8 |
