Week RS1 • 2025-09-07 • vs BAL (Home)
Season 2025
| Rank | Player | POS |
Att | Yds | Avg | TD | Long |
| 1 |
Derrick Henry |
RB |
18 |
169 |
9.4 |
2 |
49 |
| 2 |
Rasheen Ali |
RB |
1 |
5 |
5.0 |
0 |
5 |
Week RS2 • 2025-09-14 • vs NYJ (Away)
Season 2025
| Rank | Player | POS |
Att | Yds | Avg | TD | Long |
| 1 |
Breece Hall |
RB |
10 |
29 |
2.9 |
0 |
12 |
Week RS3 • 2025-09-18 • vs MIA (Home)
Season 2025
| Rank | Player | POS |
Att | Yds | Avg | TD | Long |
| 1 |
De'Von Achane |
RB |
12 |
62 |
5.2 |
0 |
14 |
| 2 |
Ollie Gordon II |
RB |
9 |
38 |
4.2 |
1 |
16 |
Week RS4 • 2025-09-28 • vs NO (Home)
Season 2025
| Rank | Player | POS |
Att | Yds | Avg | TD | Long |
| 1 |
Alvin Kamara |
RB |
15 |
70 |
4.7 |
0 |
17 |
Week RS5 • 2025-10-05 • vs NE (Home)
Season 2025
| Rank | Player | POS |
Att | Yds | Avg | TD | Long |
| 1 |
TreVeyon Henderson |
RB |
6 |
24 |
4.0 |
0 |
13 |
| 2 |
Rhamondre Stevenson |
RB |
7 |
14 |
2.0 |
2 |
7 |
Week RS6 • 2025-10-13 • vs ATL (Away)
Season 2025
| Rank | Player | POS |
Att | Yds | Avg | TD | Long |
| 1 |
Bijan Robinson |
RB |
19 |
170 |
8.9 |
1 |
81 |
| 2 |
Tyler Allgeier |
RB |
10 |
32 |
3.2 |
1 |
21 |
Week RS8 • 2025-10-26 • vs CAR (Away)
Season 2025
| Rank | Player | POS |
Att | Yds | Avg | TD | Long |
| 1 |
Rico Dowdle |
RB |
8 |
54 |
6.8 |
0 |
24 |
| 2 |
Chuba Hubbard |
RB |
12 |
34 |
2.8 |
1 |
5 |
Week RS10 • 2025-11-09 • vs MIA (Away)
Season 2025
| Rank | Player | POS |
Att | Yds | Avg | TD | Long |
| 1 |
De'Von Achane |
RB |
22 |
174 |
7.9 |
2 |
59 |
| 2 |
Jaylen Wright |
RB |
5 |
17 |
3.4 |
0 |
18 |
Week RS11 • 2025-11-16 • vs TB (Home)
Season 2025
| Rank | Player | POS |
Att | Yds | Avg | TD | Long |
| 1 |
Rachaad White |
RB |
10 |
51 |
5.1 |
0 |
12 |
| 2 |
Sean Tucker |
RB |
19 |
106 |
5.6 |
2 |
43 |
Week RS12 • 2025-11-20 • vs HOU (Away)
Season 2025
| Rank | Player | POS |
Att | Yds | Avg | TD | Long |
| 1 |
Woody Marks |
RB |
16 |
74 |
4.6 |
0 |
19 |
| 2 |
Nick Chubb |
RB |
6 |
16 |
2.7 |
0 |
7 |
Week RS13 • 2025-11-30 • vs PIT (Away)
Season 2025
| Rank | Player | POS |
Att | Yds | Avg | TD | Long |
| 1 |
Jaylen Warren |
RB |
10 |
35 |
3.5 |
1 |
12 |
| 2 |
Kenneth Gainwell |
RB |
5 |
20 |
4.0 |
0 |
11 |
Week RS14 • 2025-12-07 • vs CIN (Home)
Season 2025
| Rank | Player | POS |
Att | Yds | Avg | TD | Long |
| 1 |
Chase Brown |
RB |
12 |
23 |
1.9 |
1 |
5 |
| 2 |
Samaje Perine |
RB |
6 |
31 |
5.2 |
0 |
9 |
Week RS15 • 2025-12-14 • vs NE (Away)
Season 2025
| Rank | Player | POS |
Att | Yds | Avg | TD | Long |
| 1 |
TreVeyon Henderson |
RB |
14 |
148 |
10.6 |
2 |
65 |
| 2 |
Rhamondre Stevenson |
RB |
6 |
50 |
8.3 |
0 |
15 |
